Flavokawain A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Flavokawain A 具有抗肿瘤活性，例如抑制裸鼠模型中膀胱肿瘤细胞的生长，防止非肌层浸润性尿路上皮细胞癌的复发和进展。

Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. Flavokawain A may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

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Endocrinology/Hormones

Aromatase

p38

Others-Field

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3420-72-2

314.33

C18H18O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (318.14 mM)

COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O

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(-20℃)

With Ice Pack

≥ 2 years